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Publications from CRPS Registry Research Studies

The CRPS Registry is a long-term research study in its own right.  Researchers from other organisations can also use the Registry to recruit people for their own studies (subject to approval from the Registry Steering Committee).  Publications that have resulted from studies related to the Registry are listed below.

Abstracts (overviews) of all research papers can be accessed using the following links, but please note that some will require an active subscription to the relevant journal in order to access the full publication.

Pain Reduction by Inducing Sensory-Motor Adaptation in Complex Regional Pain Syndrome (CRPS PRISMA: Protocol for a Double-blind Randomized Controlled Trial -(pre-print, MedRxiv).  Prism Adaptation is a behavioural intervention targeted at reducing attention deficits in post-stroke hemispatial neglect.  It also appears to reduce pain and other CRPS symptoms, however, these therapeutic effects have been demonstrated only in small unblinded studies.  This paper describes the protocol for an ongoing study that will evaluate the efficacy of Prism Adaptation treatment for CRPS.  The secondary aims of the study are to examine the relationships between neuropsychological changes and clinical manifestations of CRPS, as well as symptom inmprovement.

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Sub-optimal learning of tactile-spatial predictions in patients with Complex Regional Pain Syndrome - accepted for publication in PAIN 2019.  In CRPS, tactile sensory deficits have motivated the therapeutic use of sensory discrimination training. However, the hierarchical organisation of the brain is such that low-level sensory processing can be dynamically influenced by higher-level knowledge, e.g. knowledge learnt from statistical regularities in the environment. It is unknown whether the learning of such statistical regularities is impaired in CRPS. This study employed a hierarchical Bayesian model of predictive coding to investigate statistical learning of tactile-spatial predictions in CRPS.

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A multi-centre study to explore the feasibility and acceptability of collecting data for complex regional pain syndrome clinical studies using a core measurement set: study protocol - published in Musculoskeletal Care, July 2019.  This paper relates to the latest phase of the international COMPACT study.  It explains the process for testing the collection of outcome measurement data using the recommended patient-reported questionnaire set, as well as developing an electronic system to collect and manage the data.  

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When can you say you are well again? How do people with Complex Regional Pain Syndrome define recovery? - blog published online in April 2018 via the Body in Mind website.  This gives an overview of the international Recovery study and the key findings.

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Are you better? A multi-centre study exploring the patients definition of recovery from Complex Regional Pain Syndrome - published in the European Journal of Pain, December 2017.  An in-depth analysis of the international Recovery study, which aimed to define recovery from the patients' perspective and to better understand their priorities for treatment approaches.  The data showed that a small number of themes are of highest importance to CRPS patients' definition of recovery.  Patients want their pain, movement restriction and reliance on medication to be addressed, above all other factors. These factors should therefore be foremost concerns for future treatment and rehabilitation programmes.

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Low-dose intravenous immunoglobulin treatment for long-standing Complex Regional Pain Syndrome, a randomised placebo-controlled phase III multi-centre trial - published in Annals of Internal Medicine, October 2017.  This paper focuses on the LIPs trial, which explored the effectiveness of a specific drug treatment for the reduction of pain.  The study found that low-dose immunoglobulin was not effective in relieving pain in patients with moderate to severe CRPS of 1–5 years’ duration. Better drug treatments for long-standing CRPS are urgently required.

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Data comparison made easy!  A Core Outcome Measurement set for complex regional PAin syndrome Clinical sTudies (COMPACT) - a blog published online in September 2017 via the Body in Mind website.  An overview of the process to agree an international minimum core set of standardised outcome measures for use in future CRPS clinical research.

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Recommendations for a first Core Outcome Measurement set for complex regional PAin syndrome Clinical sTudies (COMPACT) - published in PAIN (IASP research journal), 2017.  An in-depth analysis of the development of an agreed core measurement set for CRPS, using patient-reported outcomes measures.  This was the first phase of the international COMPACT study, and the feasibility of collecting data using this questionnaire set is currently being tested.

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Establishing the characteristics of patients with chronic Complex Regional Pain Syndrome: the value of the CRPS-UK Registry - published in the British Journal of Pain, 2015.  This was the first paper written specifically about the Registry, outlining its purpose and development.  The article also assesses the validity of the data and describes the characteristics of a sample of the UK CRPS population.

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